Scientist - Assay Development and Lead Discovery

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Job Title: Scientist - Assay Development and Lead Discovery
Location: South San Francisco, CA,

Company: Merck
Industry Sector: Agribusiness
Salary: Competetive
Job Description: Job Description

New hires in office-based roles in the US & Puerto Rico will be required, subject to applicable law, to demonstrate that they have been fully vaccinated for COVID-19 or qualify for a medical or religious exemption to this vaccination requirement that can be accommodated without an undue burden to the operation. However, subject to applicable law, employees working in roles that the Company determines require routine collaboration with external stakeholders, such as employees in health services, customer facing commercial, or research based roles, will be required to be fully vaccinated as a condition of employment.

Our Research Scientists are our Inventors. We identify and target steps in disease mechanisms or pathways that could be inhibited or enhanced. Our goal is to isolate a compound that is effective against a disease target. Using innovative thinking, state-of-the-art facilities and robust scientific methodology we collaborate to discover the next medical breakthrough.

Our company's Research Laboratories in South San Francisco is seeking a highly motivated Scientist with experience in biochemical/cellular assay development and lead discovery support to join our Quantitative Biosciences (Pharmacology) department. The successful candidate will be responsible for the development and execution of mid/high throughput biochemical/cellular assays and mechanistic experimentation to advance early drug discovery projects. The candidate will work closely with a team of multidisciplinary quantitative scientists to enable key assays/models and studies to advance a diverse portfolio of small molecule and biologic preclinical candidates targeting cancer, fibrosis, and cardiometabolic disorders. We value transparent communication, creative-thinking, teamwork, and rigorous scientific exploration. If you are a highly motivated individual and team player with a strong desire to impact drug discovery across multiple therapeutic areas, we invite you to consider joining our team.

Key responsibilities:

Develop and execute biochemical and/or cellular assays to support compound screening and lead discovery in multiple therapeutic areas (cardiometabolic, immunology, and oncology)
Properly document experimental design, findings, and assay protocols, and comply with all laboratory training and safety requirements
Ensure high-quality data generation, analysis, and timely reporting to project teams
Leverage lab automation to improve assay operation, quality, and overall productivity
Support automated compound management for various lead discovery projects
Evaluate and implement new enabling technologies and methods
Collaborate with colleagues on multi-disciplinary project teams to provide scientific/technical contributions and deliver project goals.

Education Minimum Requirements:

BS/MS in Biochemistry, Cell Biology, Pharmacology or a relevant scientific discipline, with a minimum of three (3) years of drug discovery experience in a biotech/pharmaceutical setting

Required Experience and Skills:

Relevant knowledge and expertise in biochemical and/or cellular assay development, as well as hands-on experience with compound screening and lead discovery support
Skilled in the development and execution of biochemical and/or cellular assays, using a wide range of experimental methods and detection technologies
Hands-on experience with various automated liquid handling instruments (Biomek, Bravo, Echo, etc.) and robotic systems for assay operation
Demonstrated ability to work collaboratively in a cross-functional team environment to advance drug discovery, with excellent organization and communication skills
Prior experience with multiple therapeutic modalities (small molecule, peptide, antibody, antibody drug conjugate, etc.) is a plus

We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we "follow the science" that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.

Who we are ...

We are known as Merck & Co., Inc., Rahway, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world.

What we look for ...

Imagine getting up in the morning for a job as important as helping to save and improve lives around the world. Here, you have that opportunity. You can put your empathy, creativity, digital mastery, or scientific genius to work in collaboration with a diverse group of colleagues who pursue and bring hope to countless people who are battling some of the most challenging diseases of our time. Our team is constantly evolving, so if you are among the intellectually curious, join us-and start making your impact today.

NOTICE FOR INTERNAL APPLICANTS

In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.

If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.

Residents of Colorado

Click here to request this role's pay range.

#EligibleforERP

For positions located in the United States and Puerto Rico - Subject to applicable law, all new hires (including internal transfers) must demonstrate that they are fully vaccinated against COVID-19 or that they qualify for a medical or religious exemption to this vaccination requirement. New hires (including internal transfers) to a position that, as determined by the Company, requires routine collaboration with external stakeholders (such as roles in health services or customer-facing commercial or research-based roles) ("Customer-Facing Role") who are not vaccinated must qualify for a medical or religious exemption and be in a position that the Company determines can accommodate unvaccinated employees without causing an undue burden to business operations. If, following dialog with the candidate as appropriate, it is determined that the candidate either a) does not qualify for a religious or medical exemption or, b) for candidates applying for Customer-Facing roles, it is determined that allowing the candidate to work without vaccination would cause an undue burden to the Company, the candidate will be ineligible for hire or transfer, or any offer of employment or transfer (if applicable) will be revoked. Please note that notwithstanding the approval of any reasonable accommodation, the Company reserves the right to monitor, modify, or revoke any such accommodation if it is determined, following dialog with the employee, that the accommodation is no longer effective or results in an undue burden to the Company.

Current Employees apply HERE

Current Contingent Workers apply HERE

US and Puerto Rico Residents Only:

Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.

For more information about personal rights under Equal Employment Opportunity, visit:

EEOC Poster

EEOC GINA Supplement

OFCCP EEO Supplement

Pay Transparency Nondiscrimination

We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively. We are an equal opportunity employer, committed to fostering an inclusive and diverse workplace.

Residents of Colorado:

Click here to request this role's pay range.

Search Firm Representatives Please Read Carefully
Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

Employee Status:
Regular

Relocation:
Domestic

VISA Sponsorship:
No

Travel Requirements:

Flexible Work Arrangements:
On-Site

Shift:
1st - Day

Valid Driving License:

Hazardous Material(s):

Number of Openings:
3

To apply please click on APPLY TO THIS POSITION

Job Post Date: 11/03/22