Principal Scientist

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Job Title: Principal Scientist
Location: New York, NY, Mid-Atlantic United States,

Company: Merck
Industry Sector: Agribusiness

Job Description: Job Description

Attention NJ Applicants : In April 2020, our Company announced plans to consolidate our New Jersey campuses into a single New Jersey headquarters location in Rahway, NJ by 2023. Therefore, the NJ work location for this role will be temporarily based and the exact timing of the departmental move to Rahway, NJ will be communicated at a future date.

Our Scientists are our Inventors. We deliver robust scientific data and interpretation that drives the commercialization of breakthrough therapeutics using innovative thinking, state-of-the-art facilities and modern equipment. Our ability to excel depends on the integrity, knowledge, imagination, skill, diversity and teamwork of people like you. To this end, we strive to create an environment of mutual respect, encouragement and teamwork. As part of our global team, you'll have the opportunity to collaborate with talented and dedicated colleagues while developing your career.

The Analytical Research and Development Mass Spectrometry group in Kenilworth, NJ is seeking an industry leader with technical expertise in mass spectrometry-based protein characterization. More specifically, the ideal candidate will have an extensive track record of advancing the development of biotherapeutics with mass spectrometry. This position has the opportunity to impact the analytical strategy for characterization of peptides, therapeutic proteins, antibody-drug conjugates, vaccines and cell therapies as well as various process residuals and formulation excipients. This Principal Scientist role will have the opportunity to influence the future direction of Mass Spectrometry within Analytical Research and Development at our company.

The ideal candidate is expected to be a leader in the field of mass spectrometry. This candidate will have an established track record for mentorship of junior talent and advancing scientific excellence through external presentations, publications, and regulatory engagements. Additionally, the candidate will have advanced knowledge for analytical experimental design and the ability to provide technical leadership for junior scientists as well as biotherapeutic pipeline programs. Finally, this Principal Scientist will be a partner in problem solving providing key leadership and driving collaboration both internally and externally.

Primary Responsibilities:
  • Lead a group of scientists focused on delivering mass spectrometry data to advance the pipeline.
  • Advance mass spectrometry methodology for peptide mapping, intact mass, native mass, HDX, sequence variants, quantitative analysis, and host cell protein analysis.
  • Author regulatory submission sections and responses, technical reports and scientific presentations.
  • Explore and develop new technologies to advance the field of mass spectrometry.
  • Demonstrate advanced multitasking, prioritization and problem-solving skills in the planning and execution of experiments.
  • Mentor and share expertise across the entire Analytical Research and Development department.
  • Champion compliance and safety as a leader both within and outside the laboratory.

Education Requirements:
  • Ph.D. in Analytical Chemistry, or Chemistry or Biological Sciences with 8+ years of biopharmaceutical industry experience.

Required Experience and Skills:
  • Expertise designing and conducting biologic mass spectrometry or proteomics experiments, including sample preparation, mass spectrometer operation and data analysis.
  • Extensive knowledge of Thermo, Sciex, Agilent and Waters instruments.
  • Expertise in multiple-reaction monitoring experiments and quantitative analysis.
  • Advanced knowledge of mass spectrometry data analysis packages and informatics platforms.
  • Experienced analytical knowledge and good understanding of biologics development, including multiple modalities such as peptides, fusion proteins, and ADCs.
  • Excellent verbal and written communications skills, as demonstrated through high impact scientific publications and presentations.

Preferred Experience and Skills:
  • Expertise in complex glycan analysis and impact on biologics structure and function.
  • Advanced knowledge of electronic laboratory notebook applications and good documentation practices.

We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we "follow the science" that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.

Who we are ...

We are known as Merck & Co., Inc., Rahway, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world.

What we look for ...

Imagine getting up in the morning for a job as important as helping to save and improve lives around the world. Here, you have that opportunity. You can put your empathy, creativity, digital mastery, or scientific genius to work in collaboration with a diverse group of colleagues who pursue and bring hope to countless people who are battling some of the most challenging diseases of our time. Our team is constantly evolving, so if you are among the intellectually curious, join us-and start making your impact today.


In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.

If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.

Residents of Colorado

Click here to request this role's pay range.

For positions located in the United States and Puerto Rico - Subject to applicable law, all new hires (including internal transfers) must demonstrate that they are fully vaccinated against COVID-19 or that they qualify for a medical or religious exemption to this vaccination requirement. New hires (including internal transfers) to a position that, as determined by the Company, requires routine collaboration with external stakeholders (such as roles in health services or customer-facing commercial or research-based roles) ("Customer-Facing Role") who are not vaccinated must qualify for a medical or religious exemption and be in a position that the Company determines can accommodate unvaccinated employees without causing an undue burden to business operations. If, following dialog with the candidate as appropriate, it is determined that the candidate either a) does not qualify for a religious or medical exemption or, b) for candidates applying for Customer-Facing roles, it is determined that allowing the candidate to work without vaccination would cause an undue burden to the Company, the candidate will be ineligible for hire or transfer, or any offer of employment or transfer (if applicable) will be revoked. Please note that notwithstanding the approval of any reasonable accommodation, the Company reserves the right to monitor, modify, or revoke any such accommodation if it is determined, following dialog with the employee, that the accommodation is no longer effective or results in an undue burden to the Company.

Current Employees apply HERE

Current Contingent Workers apply HERE

US and Puerto Rico Residents Only:

Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.

For more information about personal rights under Equal Employment Opportunity, visit:

EEOC Know Your Rights

EEOC GINA Supplement

Pay Transparency Nondiscrimination

We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively. We are an equal opportunity employer, committed to fostering an inclusive and diverse workplace.

Under New York City, Washington State and California State law, the Company is required to provide a reasonable estimate of the salary range for this job. Final determinations with respect to salary will take into account a number of factors, which may include, but not be limited to the primary work location and the chosen candidate's relevant skills, experience, and education.

Expected salary range:
$144,320.00 - $227,100.00
For Washington State Jobs, a summary of benefits is listed here .

Learn more about your rights, including under California, Colorado and other US State Acts

Search Firm Representatives Please Read Carefully
Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

Employee Status:


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Travel Requirements:

Flexible Work Arrangements:
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1st - Day

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Job Post Date: 01/22/23
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