Post Doc Discovery Pharm Sciences

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Job Title: Post Doc Discovery Pharm Sciences
Location: South San Francisco, CA, West United States,

Company: Merck
Industry Sector: Agribusiness

Job Description: Job Description

Be a part of the legacy: Postdoctoral Research Fellow Program

Our Research Laboratories' Postdoctoral Research Fellow Program aims to be a best-in-industry program for industrial postdoctoral researchers, designed to provide you with an academic focus in a commercial environment. With the resources, reach, and expertise of a large pharmaceutical company, postdoctoral researchers will be positioned to excel in an institution committed to breakthrough innovation in research and discovery.

Our company's Research Laboratories South San Francisco (SSF) Discovery Center, a wholly owned subsidiary of our company, is focused on driving discovery research. Our multi-disciplinary discovery research site offers state-of- the-art resources to explore the most promising science combined with our company's world-class R&D expertise in small molecules and biologics. Located within the heart of the Bay area's biomedical community, research conducted in our new laboratories spans exploratory biology through early clinical development and is an integral part of our company's powerful world-class network of drug and vaccine discovery.

At our company, we are inspired by the belief that a research-driven enterprise dedicated to scientific excellence can create medicines and vaccines that save and improve lives. Every employee is building on our proud legacy of scientific breakthrough. Our ability to impact the lives of patients worldwide depends on the integrity, creativity, humility, and scientific acumen of our team. We are creating a diverse organization that is inspired by invention and founded on a culture of respect and collaboration. At Our Company's Research Labs, you'll have the opportunity to expand your knowledge and skills through collaboration with talented and dedicated colleagues while advancing your career.

Discovery Pharmaceutical Sciences (DPS) enables drug discovery and drug product development through application of pharmaceutical science and drug delivery research from target identification through clinical candidate selection for both small and large molecules. DPS influences molecular design of these clinical candidates through physicochemical property profiling and applies these insights to better understand and mitigate drug product developability risks. Our deliverables also include identification of suitable oral and parenteral preclinical formulations for pharmacology and toxicology studies across a variety of administration routes and modalities (small molecules, peptides, and biologics). Our function closely collaborates with other key functions required for the progression of clinical candidate selection, including Biology, Medicinal Chemistry, Drug Safety, Process Research, Protein Engineering, Analytical Chemistry, Drug Metabolism and Pharmacokinetics.

The DPS team in SSF is seeking a highly motivated postdoc with creative passion for working on new pharmaceutical technologies. The ideal candidate should possess scientific knowledge and / or experience related to formulation and/or characterization of biologics (i.e., proteins, nucleic acids, etc.)

Postdoc Project description:

This postdoctoral project will investigate different drying technologies for producing dry biological therapeutics, build high-throughout/miniaturized drying platforms and study the impact of process engineering and formulation composition on the quality of solid protein products via advanced characterization methods.

  • Design and execute physicochemical characterization and formulation development experiments of large molecules (i.e., proteins, mAbs, etc) using techniques such as sub-visible particle characterization, HPLC and thermal and microscopy methods.
  • Learn and use various formulation process methods such as spray drying
  • Present and discuss data periodically at departmental meetings
  • Publish or patent observations where appropriate
  • Limited travel to scientific conferences and broader Pharmaceutical Sciences department meetings (

Education and Experience:
  • Ph.D. in Pharmaceutical Sciences, Chemistry, Biochemistry, Chemical / Biochemical/ Biomedical engineering, or related disciplines or with 0-4 years of industrial experience or a M.S. with 4+ years of relevant industrial experience.

Required Experience and Skills:
  • Practical experience in the characterization and formulation of biologics
  • Practical experience and/or a strong interest to learn and implement new drug delivery and analytical technologies.
  • Strong organizational and technical problem-solving skills and excellent management in driving results and innovation.
  • Ability to work independently, as well as collaboratively in a fast-paced environment.

Desired Experience and Skills:
  • Demonstrated experience solving program trials by leveraging strong scientific fundamentals in related subject areas including organic chemistry, analytical chemistry, physical chemistry, biopharmaceutics, process development, and/or engineering.
  • Experience in pre-clinical / clinical formulation development and physicochemical characterization and drug delivery of proteins.
  • Advanced data analysis and visualization skills.


We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we "follow the science" that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.

Who we are ...

We are known as Merck & Co., Inc., Rahway, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world.

What we look for ...

Imagine getting up in the morning for a job as important as helping to save and improve lives around the world. Here, you have that opportunity. You can put your empathy, creativity, digital mastery, or scientific genius to work in collaboration with a diverse group of colleagues who pursue and bring hope to countless people who are battling some of the most challenging diseases of our time. Our team is constantly evolving, so if you are among the intellectually curious, join us-and start making your impact today.

Post Doc:

Under New York City, Washington State and California State law, the Company is required to provide a reasonable estimate of the salary range for this job. Final determinations with respect to salary will take into account a number of factors, which may include, but not be limited to the primary work location and the chosen candidate's relevant skills, experience, and education.

Expected salary range:


Available benefits include bonus eligibility, health care and other insurance benefits (for employee and family), retirement benefits, paid holidays, vacation, and sick days. For Washington State Jobs, a summary of benefits is listed here .

For positions located in the United States and Puerto Rico - Subject to applicable law, all new hires (including internal transfers) must demonstrate that they are fully vaccinated against COVID-19 or that they qualify for a medical or religious exemption to this vaccination requirement. New hires (including internal transfers) to a position that, as determined by the Company, requires routine collaboration with external stakeholders (such as roles in health services or customer-facing commercial or research-based roles) ("Customer-Facing Role") who are not vaccinated must qualify for a medical or religious exemption and be in a position that the Company determines can accommodate unvaccinated employees without causing an undue burden to business operations. If, following dialog with the candidate as appropriate, it is determined that the candidate either a) does not qualify for a religious or medical exemption or, b) for candidates applying for Customer-Facing roles, it is determined that allowing the candidate to work without vaccination would cause an undue burden to the Company, the candidate will be ineligible for hire or transfer, or any offer of employment or transfer (if applicable) will be revoked. Please note that notwithstanding the approval of any reasonable accommodation, the Company reserves the right to monitor, modify, or revoke any such accommodation if it is determined, following dialog with the employee, that the accommodation is no longer effective or results in an undue burden to the Company.

Current Employees apply HERE

Current Contingent Workers apply HERE

US and Puerto Rico Residents Only:

Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.

For more information about personal rights under Equal Employment Opportunity, visit:

EEOC Know Your Rights

EEOC GINA Supplement

Pay Transparency Nondiscrimination

We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively. We are an equal opportunity employer, committed to fostering an inclusive and diverse workplace.

Residents of Colorado:

Click here to request this role's pay range.

Learn more about your rights, including under California, Colorado and other US State Acts

Search Firm Representatives Please Read Carefully
Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

Employee Status:


VISA Sponsorship:

Travel Requirements:
No Travel Required

Flexible Work Arrangements:

1st - Day

Valid Driving License:

Hazardous Material(s):
Standard chemistry lab

Number of Openings:

To apply please click on APPLY TO THIS POSITION

Job Post Date: 01/26/23
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