Company:Merck Industry Sector:Agribusiness Salary:Competetive Job Description:Job Description
Our Company's Anatomic Pathology group in South San Francisco is seeking an experienced researcher with expertise in machine learning and digital pathology to support applied research and biomarker development in oncology and other therapeutic areas. This position will require application of computer vision, machine learning, and software programming to develop custom computational methods for automating tissue based analyses and interrogating basic biological features and mechanisms of action leverageable for clinical and discovery efforts. The successful candidate will deploy convolutional neural networks in machine learning projects focused on complex feature and pattern recognition, spatial analysis, and other evaluations applied to digitized pathology images. The position requires a high level of comfort with coding (e.g. Python, MATLAB), as well as facility with deep-learning frameworks (e.g. PyTorch) with conversion of custom-coded solutions for use by non-coders. This position is interdisciplinary, sitting at the intersection of pathology, applied computer science, and therapeutic area biology, particularly oncology. An exceptional degree of collaboration is required.
Our Research Scientists are our Inventors. We identify and target steps in disease mechanisms or pathways that could be inhibited or enhanced. Our goal is to isolate a compound that is effective against a disease target. Using innovative thinking, state-of-the-art facilities and robust scientific methodology we collaborate to discover the next medical breakthrough.
The successful candidate will:
Develop and automate machine learning based tissue segmentation algorithms to replace manual annotations in image analysis workflows
Devise and implement efficient and robust parallel-computing workflows in High Performance Computing systems for large-scale image analysis projects
Develop novel spatial evaluation algorithms for interrogation of proximity relationships between tissue constituents
Write custom code for algorithm development and model training, converting custom solutions to enable use by non-coders as appropriate
Work with images from across different pathology assay types and different disease indications
Interact smoothly with pathologists, pathology bench scientists, statisticians, biologists, clinicians, and informatics/IT staff, both internally and externally
Serve as a subject matter expert regarding computational aspects of digital pathology projects
Present data in team meetings and participate in generation of technical reports in support of regulatory documents as needed
Possess a high level of self-motivation, comfort with complex multitasking, ability to work independently with minimal assistance
Have excellent communication and interpersonal skills, high levels of creativity and flexibility and highly collaborative approach
This position is remote or hybrid based on the candidate's location and preference.
Bachelor's (with 10 years), Master's (with 6 years) or Ph.D. (with 2 years) in biology, pathology, immunology, computer science or related field and relevant experience
Required Skills and Experience:
In-depth knowledge of image processing, computer vision, and statistical machine learning
Highly proficient in programming , e.g., Python and MATLAB
Familiarity and comfort with digital image analysis, preferably pathology images
Preferred Skills, and Experience:
High level of comfort with histology/microanatomy
Background in oncology and/or immunology
Previous work in the pharmaceutical industry
Practical knowledge with Perkin Elmer Vectra Polaris platform and HALO image analysis system
We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we "follow the science" that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.
Who we are ...
We are known as Merck & Co., Inc., Rahway, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world.
What we look for ...
Imagine getting up in the morning for a job as important as helping to save and improve lives around the world. Here, you have that opportunity. You can put your empathy, creativity, digital mastery, or scientific genius to work in collaboration with a diverse group of colleagues who pursue and bring hope to countless people who are battling some of the most challenging diseases of our time. Our team is constantly evolving, so if you are among the intellectually curious, join us-and start making your impact today.
NOTICE FOR INTERNAL APPLICANTS
In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.
If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.
For positions located in the United States and Puerto Rico - Subject to applicable law, all new hires (including internal transfers) must demonstrate that they are fully vaccinated against COVID-19 or that they qualify for a medical or religious exemption to this vaccination requirement. New hires (including internal transfers) to a position that, as determined by the Company, requires routine collaboration with external stakeholders (such as roles in health services or customer-facing commercial or research-based roles) ("Customer-Facing Role") who are not vaccinated must qualify for a medical or religious exemption and be in a position that the Company determines can accommodate unvaccinated employees without causing an undue burden to business operations. If, following dialog with the candidate as appropriate, it is determined that the candidate either a) does not qualify for a religious or medical exemption or, b) for candidates applying for Customer-Facing roles, it is determined that allowing the candidate to work without vaccination would cause an undue burden to the Company, the candidate will be ineligible for hire or transfer, or any offer of employment or transfer (if applicable) will be revoked. Please note that notwithstanding the approval of any reasonable accommodation, the Company reserves the right to monitor, modify, or revoke any such accommodation if it is determined, following dialog with the employee, that the accommodation is no longer effective or results in an undue burden to the Company.
Current Employees apply HERE
Current Contingent Workers apply HERE
US and Puerto Rico Residents Only:
Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.
For more information about personal rights under Equal Employment Opportunity, visit:
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We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively. We are an equal opportunity employer, committed to fostering an inclusive and diverse workplace.
Residents of Colorado:
Click here to request this role's pay range.
Search Firm Representatives Please Read Carefully Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.
Employee Status: Regular
VISA Sponsorship: Yes
Flexible Work Arrangements:
Valid Driving License:
Number of Openings: 2
To apply please click on APPLY TO THIS POSITION
Job Post Date: 11/03/22
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