Job Title:Associate Principal Scientist - Cardiometabolic Disease, Quantitative Pharmacology and Pharmacometrics (R4) Location:New York, NY,
Company:Merck Industry Sector:Agribusiness Salary:Competetive Job Description:Job Description
The Quantitative Pharmacology and Pharmacometrics (QP2) Department of our company's Research Laboratories in West Point, PA / Rahway, NJ is seeking a curious and collaborative Associate Principal Scientist group to support programs targeting cardiometabolic disorders.
As an Associate Principal Scientist, you will participate on cross-functional teams of experienced scientists to discover and advance the clinical development of novel therapeutic agents for cardiometabolic diseases. More specifically, you will apply your quantitative skills with minimal supervision to develop and implement translational PK/PD strategies, characterize clinical population pharmacokinetics and pharmacodynamics of biologics, small molecules and non-traditional therapeutics like peptides and novel biological constructs, perform clinical trial simulations, comparator modeling and other model-based analyses to inform dose selection and schedule, clinical trial design and go/no-go decisions. You will apply your expertise to frame critical drug development questions to optimize drug development using model-based approaches and influence cross-functional teams to adopt such strategies. Finally, you will acquire an understanding of global regulatory expectations and contribute to regulatory documents and interactions with agencies.
The Associate Principal Scientist is a quantitative drug developer, with an integrated understanding of the strategic elements of drug discovery and development from a clinical pharmacology and modeling perspective. The ideal candidate is collaborative, possesses a learning mindset and can work through scientific challenges within and between departments to develop aligned strategies and solutions. In addition, you share your skills and ideas with junior scientists and with the broader QP2 department to advance our science. Excellent communication skills are required including the ability to clearly present scientific data in group settings.
Within QP2, you have a unique opportunity to accelerate your professional career as a quantitative drug developer taking advantage of our end-to-end pipeline support in one of the world's most research-intensive biopharmaceutical companies.
A Ph.D. or equivalent degree with at least 3 years of experience - OR- a PharmD or equivalent degree with at least 5 years of experience - OR- a MS or equivalent degree with at least 7 years of experience, where "experience" means having a record of increasing responsibility and independence in a similar role in pharmaceutical drug development or academia
An educational background in PK/PD, pharmaceutical sciences, pharmacometrics, mathematics, statistics/ biostatistics, computational biology/chemistry, or chemical/biomedical engineering.
Experience in performing population PK / PKPD analyses using standard pharmacometric software (e.g. NONMEM, Monolix, Phoenix, R, Matlab)
Proficiency in written and verbal communication and interdisciplinary collaboration
An exemplary record of increasing responsibility, independence, and demonstrated impact in driving drug development decisions through application of model-based approaches
Knowledge of cardiometabolic disorders
Skills in experimental design, mathematical problem solving, critical data analysis/interpretation, and statistics
Scientific understanding of ADME and biopharmaceutic properties of biologics, small molecules, or non-traditional therapeutics
Demonstrated ability to effectively participate in an interdisciplinary team
Your role at our company is integral to helping the world meet new breakthroughs that affect generations to come, and we're counting on your skills and inventiveness to help make meaningful contributions to global medical advancement. At our company, we're inventing for life.
We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we "follow the science" that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.
Who we are ...
We are known as Merck & Co., Inc., Rahway, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world.
What we look for ...
Imagine getting up in the morning for a job as important as helping to save and improve lives around the world. Here, you have that opportunity. You can put your empathy, creativity, digital mastery, or scientific genius to work in collaboration with a diverse group of colleagues who pursue and bring hope to countless people who are battling some of the most challenging diseases of our time. Our team is constantly evolving, so if you are among the intellectually curious, join us-and start making your impact today.
NOTICE FOR INTERNAL APPLICANTS
In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.
If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.
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For positions located in the United States and Puerto Rico - Subject to applicable law, all new hires (including internal transfers) must demonstrate that they are fully vaccinated against COVID-19 or that they qualify for a medical or religious exemption to this vaccination requirement. New hires (including internal transfers) to a position that, as determined by the Company, requires routine collaboration with external stakeholders (such as roles in health services or customer-facing commercial or research-based roles) ("Customer-Facing Role") who are not vaccinated must qualify for a medical or religious exemption and be in a position that the Company determines can accommodate unvaccinated employees without causing an undue burden to business operations. If, following dialog with the candidate as appropriate, it is determined that the candidate either a) does not qualify for a religious or medical exemption or, b) for candidates applying for Customer-Facing roles, it is determined that allowing the candidate to work without vaccination would cause an undue burden to the Company, the candidate will be ineligible for hire or transfer, or any offer of employment or transfer (if applicable) will be revoked. Please note that notwithstanding the approval of any reasonable accommodation, the Company reserves the right to monitor, modify, or revoke any such accommodation if it is determined, following dialog with the employee, that the accommodation is no longer effective or results in an undue burden to the Company.
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We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively. We are an equal opportunity employer, committed to fostering an inclusive and diverse workplace.
Under New York City law, the Company is required to provide a reasonable estimate of the salary range for this job. Final determinations with respect to salary will take into account a number of factors, which may include, but not be limited to the primary work location and the chosen candidate's relevant skills, experience, and education.
Expected salary range: $129,800.00 - $220,500.00
Search Firm Representatives Please Read Carefully Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.
Employee Status: Regular
VISA Sponsorship: Yes
Travel Requirements: 10%
Flexible Work Arrangements: Hybrid
Valid Driving License:
Number of Openings: 1
To apply please click on APPLY TO THIS POSITION
Job Post Date: 11/03/22
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