Principal Scientist, Spatial & Multi-omics Computational Lead

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Job Title: Principal Scientist, Spatial & Multi-omics Computational Lead
Location: Cambridge, MA,

Company: Merck
Industry Sector: Agribusiness
Salary: Competetive
Job Description: Job Description

We are seeking an experienced leader with expertise in building computational tools for spatial transcriptomics and multi-omics single cell sequencing technologies to join the Genome Sciences (GS) team within the Department of Data & Genome Sciences (DGS) at Our Company's Research Laboratories in Cambridge, MA. Our group utilizes innovative Spatial Transcriptomics (Visium, MERSCOPE, CosMx, Xenium) and multi-omics single cell approaches (REAP-seq/CITE-seq, CROP-seq/Perturb-Seq, Immune profiling, Multiome ATAC-seq) to impact all stages of the drug development pipeline from pre-clinical to clinical development. Genome Sciences collaborates closely with the discovery therapeutic areas (i.e., oncology, immunology, neuroscience and cardiometabolic disease) and functional areas (i.e. Data & Genome Sciences, Data Science & Scientific Informatics, Quantitative Bioscience, and ChemBio) within the Discovery, Preclinical and Translational Medicine (DPTM) organization to leverage these leading edge technologies for novel target and biomarker identification and validation or to better understand therapeutic mechanisms of action for diseases with high unmet need.

We are seeking a passionate scientific leader who will be responsible for managing a team of computational scientists focused on developing, implementing and utilizing novel computational tools and pipelines. This individual and team will work together with data scientists and experimental biologists to derive impacts from these innovative and leading-edge wet lab technologies and computational tools.

The responsibilities of the candidate include but are not limited to:
  • Leadership and management of a team of scientists with broad expertise in developing and leveraging computational tools and platforms for spatial and multi-omics sequencing technologies.
  • Collaborate closely with experimental biologists within GS to build computational tools and platforms for the high throughput leading-edge multi-omics technologies they are building in the wet lab
  • Collaborate with data scientists and experimental biologists to leverage these innovative and leading-edge wet lab technologies and computational tools for maximal impact on the drug development pipeline
  • Work closely with IT and bioinformatic groups across our Research & Development Division to communicate and coordinate data analysis needs for establishing new bioinformatic pipelines or modifying existing pipelines to ensure timely analysis
  • Excellent written and verbal communication of study results to project teams and leadership
  • Foster a high-performing culture of collaboration, engagement, self-accountability and inclusion
  • Establish strong relationships within and across highly collaborative, multidisciplinary teams to effectively drive early drug discovery initiatives

Education Minimum Requirement:

Ph.D. degree with 8+ years of post-graduate experience

Required skills and experiences:
  • A proven track record of building computational tools across a wide range of high throughput genomic and high content imaging technologies (i.e., multi-omics single cell sequencing, spatial transcriptomics, digital pathology) and integration with other omics data
  • Expertise with developing and/or implementing novel data analysis tools and interactive visualization interfaces for biologists without computational backgrounds to enable rapid technology development cycles and exploration of the data
  • Experience managing a group of scientists with a track record of achievements, driving group strategy, and leading projects
  • Ability to build strong relationships within a highly collaborative, multidisciplinary teams to effectively drive early drug discovery initiatives
  • Highly self-motivated and capable of prioritizing deliverables among multiple simultaneous projects
  • Excellent attention to detail and strong communication (oral and written) skills
  • Expertise in multiple programming languages, such as R and Python
  • Expertise with high-performance Linux cluster and cloud computing
  • Experience with reproducible research tools and version control
  • Familiarity with data visualization packages, such as R Shiny, ggplot, or plotly

Preferred Experience and Skills:
  • Previous experience in pharmaceutical and/or biotechnology industry
  • Previous experience with image analyses
  • Previous experience with artificial intelligence, machine learning and/or statistical learning techniques
  • Previous experience with wet lab experiments
  • Publications in high impact journal.

We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we "follow the science" that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.

Who we are ...

We are known as Merck & Co., Inc., Rahway, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world.

What we look for ...

Imagine getting up in the morning for a job as important as helping to save and improve lives around the world. Here, you have that opportunity. You can put your empathy, creativity, digital mastery, or scientific genius to work in collaboration with a diverse group of colleagues who pursue and bring hope to countless people who are battling some of the most challenging diseases of our time. Our team is constantly evolving, so if you are among the intellectually curious, join us-and start making your impact today.


In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.

If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.

Residents of Colorado

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For positions located in the United States and Puerto Rico - Subject to applicable law, all new hires (including internal transfers) must demonstrate that they are fully vaccinated against COVID-19 or that they qualify for a medical or religious exemption to this vaccination requirement. New hires (including internal transfers) to a position that, as determined by the Company, requires routine collaboration with external stakeholders (such as roles in health services or customer-facing commercial or research-based roles) ("Customer-Facing Role") who are not vaccinated must qualify for a medical or religious exemption and be in a position that the Company determines can accommodate unvaccinated employees without causing an undue burden to business operations. If, following dialog with the candidate as appropriate, it is determined that the candidate either a) does not qualify for a religious or medical exemption or, b) for candidates applying for Customer-Facing roles, it is determined that allowing the candidate to work without vaccination would cause an undue burden to the Company, the candidate will be ineligible for hire or transfer, or any offer of employment or transfer (if applicable) will be revoked. Please note that notwithstanding the approval of any reasonable accommodation, the Company reserves the right to monitor, modify, or revoke any such accommodation if it is determined, following dialog with the employee, that the accommodation is no longer effective or results in an undue burden to the Company.

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US and Puerto Rico Residents Only:

Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.

For more information about personal rights under Equal Employment Opportunity, visit:

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Pay Transparency Nondiscrimination

We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively. We are an equal opportunity employer, committed to fostering an inclusive and diverse workplace.

Residents of Colorado:

Click here to request this role's pay range.

Search Firm Representatives Please Read Carefully
Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

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Job Post Date: 11/08/22
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