Associate Principal Scientist: High-Content Screening and Cell-Painting

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Job Title: Associate Principal Scientist: High-Content Screening and Cell-Painting
Location: New York, NY,

Company: Merck
Industry Sector: Agribusiness
Salary: Competetive
Job Description: Job Description

Our Research Scientists are our Inventors. We identify and target steps in disease mechanisms or pathways that could be inhibited or enhanced. Our goal is to isolate a compound that is effective against a disease target. Using innovative thinking, state-of-the-art facilities and robust scientific methodology we collaborate to discover the next medical breakthrough.

The Screening & Compound Profiling Group is seeking a highly motivated Associate Principal Scientist with a strong background in the development of physiological relevant cellular assays to join our Quantitative Biosciences Department at our Research Laboratories in Kenilworth, NJ. The primary responsibilities of the successful candidate will be to develop high-content screening assays to support screening small molecules, peptides and arrayed CRISPR for oncology, immunology, neuroscience and cardiovascular disease areas. The ideal candidate will have experience with cell-painting phenotypic assays and have a good understanding of advances in image and data analysis methods using machine and deep learning. Knowledge and understanding of miniaturized assays (384/1536 well) and downstream detectors ranging from standard luminescence-/fluorescence-based readouts to imaging and cell-microarray based platforms is desired. Using innovative thinking, state-of-the-art facilities, and robust scientific methodology we collaborate to discover the next medical breakthrough.

Key Functions

Work independently and as a Team member with Integrity | Precision | Accomplishment | Motivational Ambition | Respect | Inclusion
Experience with high-content phenotypic screening and analysis, ideally experience with cell-painting.
Experience in cellular assay development with proficiency in high-content screening and image analysis using primary cultures and cell lines
Focus on high throughput complex cell models (3D, iPSC, co-culture systems) to enable the development of 'assays at scale'
Ability and willingness to think "outside the box" to develop and adopt emerging cell biology technologies to support HTS (i.e. microfluidics, cell microarray platforms)
Collaborate with Project teams to develop innovative approaches to target-based and phenotypic screening for small molecule discovery efforts
Oversee and manage the design, planning and execution of robust scientific research activities
Solid understanding of data analysis workflows and statistical principles as well as AI/ML used in screening
Preference will be given to candidates with experience in complex image and data analysis methods.
Collaborate in an integrated, multidisciplinary team environment

Education

Ph.D. in Biology or equivalent plus > 5 years' experience in cellular pharmacology, HTS and/or cell-based assay development

Required

Bachelor's degree: 12 years' experience | Master's Degree: 8 years' experience | PhD Degree: 5 years' experience (experience must be in assay development and high throughput screening, with the ability to succeed in a collaborative, highly matrixed environment)

We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we "follow the science" that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.

Who we are ...

We are known as Merck & Co., Inc., Rahway, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world.

What we look for ...

Imagine getting up in the morning for a job as important as helping to save and improve lives around the world. Here, you have that opportunity. You can put your empathy, creativity, digital mastery, or scientific genius to work in collaboration with a diverse group of colleagues who pursue and bring hope to countless people who are battling some of the most challenging diseases of our time. Our team is constantly evolving, so if you are among the intellectually curious, join us-and start making your impact today.

NOTICE FOR INTERNAL APPLICANTS

In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.

If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.

For positions located in the United States and Puerto Rico - Subject to applicable law, all new hires (including internal transfers) must demonstrate that they are fully vaccinated against COVID-19 or that they qualify for a medical or religious exemption to this vaccination requirement. New hires (including internal transfers) to a position that, as determined by the Company, requires routine collaboration with external stakeholders (such as roles in health services or customer-facing commercial or research-based roles) ("Customer-Facing Role") who are not vaccinated must qualify for a medical or religious exemption and be in a position that the Company determines can accommodate unvaccinated employees without causing an undue burden to business operations. If, following dialog with the candidate as appropriate, it is determined that the candidate either a) does not qualify for a religious or medical exemption or, b) for candidates applying for Customer-Facing roles, it is determined that allowing the candidate to work without vaccination would cause an undue burden to the Company, the candidate will be ineligible for hire or transfer, or any offer of employment or transfer (if applicable) will be revoked. Please note that notwithstanding the approval of any reasonable accommodation, the Company reserves the right to monitor, modify, or revoke any such accommodation if it is determined, following dialog with the employee, that the accommodation is no longer effective or results in an undue burden to the Company.

Current Employees apply HERE

Current Contingent Workers apply HERE

US and Puerto Rico Residents Only:

Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.

For more information about personal rights under Equal Employment Opportunity, visit:

EEOC Poster

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Pay Transparency Nondiscrimination

We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively. We are an equal opportunity employer, committed to fostering an inclusive and diverse workplace.

Under New York City law, the Company is required to provide a reasonable estimate of the salary range for this job. Final determinations with respect to salary will take into account a number of factors, which may include, but not be limited to the primary work location and the chosen candidate's relevant skills, experience, and education.

Expected salary range:
$117,600.00 - $200,100.00

Search Firm Representatives Please Read Carefully
Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

Employee Status:
Regular

Relocation:
International

VISA Sponsorship:
Yes

Travel Requirements:
10%

Flexible Work Arrangements:
On-Site

Shift:
Not Indicated

Valid Driving License:
No

Hazardous Material(s):

Number of Openings:
1

To apply please click on APPLY TO THIS POSITION

Job Post Date: 11/03/22