Associate Principal Scientist, AI/ML for Molecular Drug Design

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Job Title: Associate Principal Scientist, AI/ML for Molecular Drug Design
Location: South San Francisco, CA,

Company: Merck
Industry Sector: Agribusiness
Salary: Competetive
Job Description: Job Description

Our Company's Research Laboratories South San Francisco, is focused on driving discovery research. Our new multi-disciplinary discovery research site offers state-of-the-art resources to explore the most promising science combined with our company's world-class research and discovery expertise in small molecules and biologics. Located within the heart of the Bay Area's biomedical community, research conducted in our new laboratories spans exploratory biology through early clinical development and is an integral part of our company's powerful world-class network of drug and vaccine discovery.

At our company, we are inspired by the belief that a research-driven enterprise dedicated to scientific excellence can create medicines and vaccines that save and improve lives. Every employee is building on our proud legacy of scientific breakthrough. Our ability to impact the lives of patients worldwide relies on the integrity, creativity, humility and scientific acumen of our team. We are creating a diverse organization that is inspired by invention and founded on a culture of respect and collaboration. At Our Company's Research Labs South San Francisco, you'll have the opportunity to expand your knowledge and skills through partnership with talented and dedicated colleagues while advancing your career.

Our company is currently seeking a highly motivated and exceptional scientist with a focus on developing and applying AI/ML approaches in protein and small molecule modeling in the Computational and Structural Chemistry department at our South San Francisco site. The successful candidate will join multidisciplinary, highly collaborative discovery teams both locally and across the global of our company's network to contribute to the invention of novel biologics and small molecule medicines. This role involves both development of innovative computational methods as well as direct application of the methods to the invention of novel medicines.

Key Job Duties:

Developing new workflows, including deep learning workflows, that enable the discovery of new medicines
Collaborating with interdisciplinary discovery teams to apply a variety of informatics and modeling techniques to accelerate the evolution of drug discovery leads to drug candidates
Continuing research in areas of machine learning and molecular modeling relevant to drug discovery, and maintaining an external scientific presence through high-impact publications and presentations
Education, mentoring, and sharing of AI/ML knowledge with other AI/ML team members, the department, and adjacent groups
Potential mentoring and development responsibilities for direct report(s)

Position Qualifications:

Education:

M.S./M.A. (with 8 years) or Ph.D. (with 3 years) in computer science, applied math, engineering, biophysics, biochemistry, chemistry, or equivalent and related experience

Required Experience and Skills:

Two (2) years of experience adapting or applying deep learning methods to problems relevant to the life sciences and/or drug discovery
Two (2) years of prior work with a major deep learning framework (PyTorch, TensorFlow, JAX, or similar)
Proficiency in Python for scientific computing, including NumPy/SciPy
Knowledge of machine learning best practices
Multiple publications or external presentations demonstrating creative application of computational approaches
Highly self-motivated, with excellent attention to detail and strong organizational and communication (oral and written) skills

Preferred Experience and Skills:

Three (3) years of machine learning and deep learning work history
Prior work with computational design software such as Rosetta, MOE, or Schrodinger
Prior work with 3D molecular design for drug discovery
Knowledge of good software practices and proficiency at using code versioning tools (such as Git) in a collaborative environment
Has worked in multidisciplinary teams that include experimental scientists

The quality of our team is essential to our success. We are creating a new and innovative approach to rewarding our employees and establishing a comprehensive value proposition. Our competitive compensation program and benefits are designed to support the wide range of goals, needs and lifestyles of our employees, and the people that matter the most in their lives. If you need an accommodation for the application process please email us.

Our Company is an equal opportunity employer, Minority/Female/Disability/Veteran - proudly embracing diversity in all of its manifestations.

We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we "follow the science" that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.

Who we are ...

We are known as Merck & Co., Inc., Rahway, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world.

What we look for ...

Imagine getting up in the morning for a job as important as helping to save and improve lives around the world. Here, you have that opportunity. You can put your empathy, creativity, digital mastery, or scientific genius to work in collaboration with a diverse group of colleagues who pursue and bring hope to countless people who are battling some of the most challenging diseases of our time. Our team is constantly evolving, so if you are among the intellectually curious, join us-and start making your impact today.

NOTICE FOR INTERNAL APPLICANTS

In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.

If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.

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For positions located in the United States and Puerto Rico - Subject to applicable law, all new hires (including internal transfers) must demonstrate that they are fully vaccinated against COVID-19 or that they qualify for a medical or religious exemption to this vaccination requirement. New hires (including internal transfers) to a position that, as determined by the Company, requires routine collaboration with external stakeholders (such as roles in health services or customer-facing commercial or research-based roles) ("Customer-Facing Role") who are not vaccinated must qualify for a medical or religious exemption and be in a position that the Company determines can accommodate unvaccinated employees without causing an undue burden to business operations. If, following dialog with the candidate as appropriate, it is determined that the candidate either a) does not qualify for a religious or medical exemption or, b) for candidates applying for Customer-Facing roles, it is determined that allowing the candidate to work without vaccination would cause an undue burden to the Company, the candidate will be ineligible for hire or transfer, or any offer of employment or transfer (if applicable) will be revoked. Please note that notwithstanding the approval of any reasonable accommodation, the Company reserves the right to monitor, modify, or revoke any such accommodation if it is determined, following dialog with the employee, that the accommodation is no longer effective or results in an undue burden to the Company.

Current Employees apply HERE

Current Contingent Workers apply HERE

US and Puerto Rico Residents Only:

Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.

For more information about personal rights under Equal Employment Opportunity, visit:

EEOC Poster

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We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively. We are an equal opportunity employer, committed to fostering an inclusive and diverse workplace.

Residents of Colorado:

Click here to request this role's pay range.

Search Firm Representatives Please Read Carefully
Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

Employee Status:
Regular

Relocation:
Domestic

VISA Sponsorship:
Yes

Travel Requirements:
No Travel Required

Flexible Work Arrangements:
Flex Time

Shift:
1st - Day

Valid Driving License:
No

Hazardous Material(s):

Number of Openings:
1

To apply please click on APPLY TO THIS POSITION

Job Post Date: 11/03/22